Largazole Pharmacokinetics in Rats by LC-MS/MS
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چکیده
منابع مشابه
Largazole Pharmacokinetics in Rats by LC-MS/MS
A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extracted with ethyl acetate from human or rat plasma along with the internal standard, harmine. Samples were separated on an Onyx Monolithic C18 column b...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2014
ISSN: 1660-3397
DOI: 10.3390/md12031623